抗血清淀粉样蛋白A（SAA）的一些特性：SAA与白蛋白结合对沉淀的抑制作用。
Some properties of antisera to serum amyloid A protein (SAA): inhibition of precipitation by complexing of SAA to albumin.
作者信息
Franklin E C
出版信息
J Exp Med. 1976 Dec 1;144(6):1679-82. doi: 10.1084/jem.144.6.1679.
Abstract
Three potent rabbit antisera to human serum amyloid A protein (SAA) appear to be directed exclusibely to the carboxy terminal region not shared with the tissue amyloid A protein. Since binding to albumin completely blocks the reaction of these antisera with the antigen, and since SAA exists in serum complexed to albumin, the anti-SAA cannot be used to detect or quantitate this serum component. The possibility that similar problems will be encountered with immunoassays for molecules that exist complexed to other proteins is discussed.
摘要
三种高效的抗人血清淀粉样蛋白A（SAA）兔抗血清似乎仅针对与组织淀粉样蛋白A不共有的羧基末端区域。由于与白蛋白结合会完全阻断这些抗血清与抗原的反应，并且由于SAA在血清中与白蛋白形成复合物存在，因此抗SAA不能用于检测或定量这种血清成分。文中讨论了对于与其他蛋白质形成复合物存在的分子进行免疫测定时可能遇到类似问题的可能性。
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