纸浆厂废水在沙门氏菌和酿酒酵母检测中的遗传毒性活性。

Genotoxic activity of pulp mill effluent in Salmonella and Saccharomyces cerevisiae assays.

作者信息

Kamra O P, Nestmann E R, Douglas G R, Kowbel D J, Harrington T R

出版信息

Mutat Res. 1983 Sep;118(4):269-76. doi: 10.1016/0165-1218(83)90210-0.

Abstract

An XAD-2 resin concentrate of chlorination-stage pulp mill effluent was found to induce mutations in Salmonella typhimurium strains TA1535, TA100 and TA98 but not in strains TA1537 or TA1538. The presence of either S9 mix, S9 mix without cofactors, or heat-inactivated S9 mix, reduced the mutagenic effects. Dose-related increases in gene conversion, mitotic recombination and aberrant colony formation in Saccharomyces cerevisiae strain D7 also were found.

摘要

研究发现，氯化阶段纸浆厂废水的XAD - 2树脂浓缩物可诱导鼠伤寒沙门氏菌TA1535、TA100和TA98菌株发生突变，但不会诱导TA1537或TA1538菌株突变。添加S9混合液、不含辅因子的S9混合液或热灭活的S9混合液，均可降低诱变效应。此外，还发现酿酒酵母D7菌株的基因转化、有丝分裂重组和异常菌落形成存在剂量相关的增加。