Dawson P, Becker A, Holton J M
Br J Radiol. 1983 Nov;56(671):809-15. doi: 10.1259/0007-1285-56-671-809.
Some water-soluble radiological contrast agents have been shown to have anti-bacterial activity, a phenomenon which might interfere with bacterial cultures from body fluids containing contrast media. The new low-osmolality contrast media are known to achieve much higher urinary concentrations than their predecessors in intravenous urography, and any anti-bacterial properties they might possess could be especially important in this examination. These agents have been examined with some conventional counterparts for anti-bacterial activity against a range of common pathogens with some positive results. Several parameters which might be thought to play a role in the phenomenon--osmolality, free iodide, pH and the methylglucamine radical--have been examined and eliminated. The bactericidal effect manifested by several contrast agents was found to be eliminated in the presence of urine, dispelling fears for urine cultures following urography, but a theoretical problem still remains in examinations of the biliary tract with some of the media.
一些水溶性放射造影剂已被证明具有抗菌活性，这一现象可能会干扰来自含有造影剂的体液的细菌培养。已知新型低渗造影剂在静脉肾盂造影中比其前身能达到高得多的尿液浓度，而且它们可能具有的任何抗菌特性在这项检查中可能尤为重要。已将这些制剂与一些传统同类制剂进行了比较，检测它们对一系列常见病原体的抗菌活性，结果呈阳性。对一些可能被认为在该现象中起作用的参数——渗透压、游离碘、pH值和甲基葡糖胺基团——进行了检测并排除。发现几种造影剂表现出的杀菌作用在有尿液存在时会消失，消除了对肾盂造影后尿液培养的担忧，但对于某些造影剂用于胆道检查时仍存在一个理论问题。
