9α-氟皮质醇对人体血压及代谢的不同影响

Differential blood pressure and metabolic effects of 9 alpha-fluorocortisol in man.

作者信息

Whitworth J A, Saines D, Thatcher R

出版信息

Clin Exp Pharmacol Physiol. 1983 May-Jun;10(3):351-4. doi: 10.1111/j.1440-1681.1983.tb00211.x.

DOI:10.1111/j.1440-1681.1983.tb00211.x

Abstract

The blood pressure and metabolic effects of 9 alpha-fluorocortisol at 0.15 mg/day and 1.5 mg/day were examined in man. At high dose, systolic pressure and body weight rose, and plasma [K+], urinary sodium excretion and renin concentration fell. At low dose similar metabolic effects were seen but blood pressure was unchanged. 9 alpha-Fluorocortisol has 'mineralocorticoid' effects in man at a dose which does not alter blood pressure. These studies do not provide evidence of a 'hypertensinogenic' class of steroid hormone action in man.

摘要

研究了每天服用0.15毫克和1.5毫克的9α-氟皮质醇对人体血压和代谢的影响。高剂量时，收缩压和体重上升，血浆[K+]、尿钠排泄和肾素浓度下降。低剂量时可见类似的代谢作用，但血压未变。9α-氟皮质醇在人体中以不改变血压的剂量产生“盐皮质激素”作用。这些研究未提供人类中存在一类“致高血压”类固醇激素作用的证据。