Differential blood pressure and metabolic effects of 9 alpha-fluorocortisol in man.
作者信息
Whitworth J A, Saines D, Thatcher R
出版信息
Clin Exp Pharmacol Physiol. 1983 May-Jun;10(3):351-4. doi: 10.1111/j.1440-1681.1983.tb00211.x.
Abstract
The blood pressure and metabolic effects of 9 alpha-fluorocortisol at 0.15 mg/day and 1.5 mg/day were examined in man. At high dose, systolic pressure and body weight rose, and plasma [K+], urinary sodium excretion and renin concentration fell. At low dose similar metabolic effects were seen but blood pressure was unchanged. 9 alpha-Fluorocortisol has 'mineralocorticoid' effects in man at a dose which does not alter blood pressure. These studies do not provide evidence of a 'hypertensinogenic' class of steroid hormone action in man.
摘要
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