钾负荷对绵羊体内9-α-氟皮质醇的升压和代谢作用的影响。

The influence of potassium loading on the pressor and metabolic effects of 9-alpha-fluoro-cortisol in sheep.

作者信息

Mills E H, Coghlan J P, Denton D A, Nelson M A, Spence C D, Whitworth J A, Scoggins B A

出版信息

Clin Exp Hypertens A. 1984;6(9):1601-12. doi: 10.3109/10641968409044072.

DOI:10.3109/10641968409044072

Abstract

9 alpha-Fluorocortisol (9 alpha FF) is an analogue of cortisol with 'mineralocorticoid', 'glucocorticoid' and 'hypertensinogenic' activity. 9 alpha FF was infused at 2 mg/day for 5 days to sheep receiving a normal Na intake (100 mmol/d) and a high K intake (congruent to 800 mmol/d). K loading modified the Na retaining effects of 9 alpha FF but had no effect on the development of the hypertension. These experiments suggest that the effects of K loading on the development of 9 alpha-FF hypertension are not related simply to the effects that K has on modifying the Na retaining effects of the steroid.

摘要

9α-氟皮质醇（9α-FF）是一种具有“盐皮质激素”、“糖皮质激素”和“致高血压”活性的皮质醇类似物。以每天2毫克的剂量给正常钠摄入量（100毫摩尔/天）和高钾摄入量（约800毫摩尔/天）的绵羊输注9α-FF，持续5天。钾负荷改变了9α-FF的保钠作用，但对高血压的发展没有影响。这些实验表明，钾负荷对9α-氟皮质醇性高血压发展的影响并不简单地与钾对改变该类固醇保钠作用的影响相关。