Mungavin J M, Clarke T K
Curr Med Res Opin. 1983;8(7):461-71. doi: 10.1185/03007998309109783.
Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis. Two hundred and seventy-seven general practitioners provided completed case records for 856 patients, 373 with rheumatoid arthritis and 483 with osteoarthritis. Approximately half of the patients received tiaprofenic acid and the remainder one of the other drugs. Results showed that tiaprofenic acid was at least as effective as the other drugs. The incidence of side-effects was similar for each group except in the osteoarthritis trial where there was a higher incidence in the patients receiving indomethacin. The overall withdrawal rate from each trial was 4.6% and 5.2% in rheumatoid arthritis and osteoarthritis, respectively.
开展了两项多中心全科医疗研究，将噻洛芬酸（“苏灵大”）与其他五种非甾体抗炎药（布洛芬、吲哚美辛、萘普生、吡罗昔康和苯恶洛芬）进行比较，一项针对类风湿性关节炎患者，另一项针对骨关节炎患者。277名全科医生提供了856例患者的完整病例记录，其中373例为类风湿性关节炎患者，483例为骨关节炎患者。约一半患者服用噻洛芬酸，其余患者服用其他药物中的一种。结果显示，噻洛芬酸的疗效至少与其他药物相当。除骨关节炎试验中服用吲哚美辛的患者副作用发生率较高外，各药物组的副作用发生率相似。类风湿性关节炎试验和骨关节炎试验的总体停药率分别为4.6%和5.2%。
