Newman W P, Brodows R G
J Clin Endocrinol Metab. 1983 Dec;57(6):1102-6. doi: 10.1210/jcem-57-6-1102.
The effect of aspirin on glucose and insulin metabolism was examined with the hyperglycemic clamp technique in 8 normal volunteers. When the plasma glucose concentration was acutely raised and maintained at 125 mg/dl above the basal level after treatment with aspirin (3 g daily for 3 days), acute (0-10 min) and sustained (20-120 min) insulin release were 70% and 45% greater than before treatment. Despite the increased plasma insulin level, the glucose infusion rate remained unchanged (8 +/- 0.9 to 9.1 +/- 1.2 mg/kg X min). Consequently, the ratio of the glucose infusion rate to the plasma insulin level, an index of tissue sensitivity to endogenous insulin, decreased by 30%, indicative of impaired insulin action. Aspirin did not alter fasting levels of FFA. When ibuprofen, another prostaglandin synthesis inhibitor, was given to 10 normal volunteers, only an effect on acute insulin release could be demonstrated. These results demonstrate that aspirin not only enhances beta-cell sensitivity to glucose, but also impairs glucose metabolism in insulin-sensitive tissues. It is not clear whether these effects are related to aspirin's ability to inhibit prostaglandin synthesis.
采用高血糖钳夹技术，在8名正常志愿者中研究了阿司匹林对葡萄糖和胰岛素代谢的影响。在用阿司匹林治疗（每日3克，共3天）后，当血浆葡萄糖浓度急性升高并维持在高于基础水平125毫克/分升时，急性（0 - 10分钟）和持续（20 - 120分钟）胰岛素释放比治疗前分别增加了70%和45%。尽管血浆胰岛素水平升高，但葡萄糖输注速率保持不变（从8±0.9变为9.1±1.2毫克/千克×分钟）。因此，葡萄糖输注速率与血浆胰岛素水平之比（组织对内源性胰岛素敏感性的指标）下降了30%，表明胰岛素作用受损。阿司匹林未改变游离脂肪酸的空腹水平。当给10名正常志愿者服用另一种前列腺素合成抑制剂布洛芬时，仅显示出对急性胰岛素释放有影响。这些结果表明，阿司匹林不仅增强了β细胞对葡萄糖的敏感性，还损害了胰岛素敏感组织中的葡萄糖代谢。目前尚不清楚这些作用是否与阿司匹林抑制前列腺素合成的能力有关。
