Kellow J E, Barr G D, Middleton W R, Piper D W
J Clin Gastroenterol. 1983 Oct;5(5):417-20. doi: 10.1097/00004836-198310000-00008.
A double-blind trial using 51 outpatients was aimed at comparing the effectiveness of colloidal bismuth subcitrate (C.B.S.) in tablet and liquid form in the healing of duodenal ulcer. Criteria of entry included endoscopically proven duodenal ulcer, duration of symptoms greater than 4 weeks, and the absence of other major systemic disease. Patients were given either C.B.S. tablets (1 four times daily) or C.B.S. liquid (5 ml four times daily) for 4 weeks. Ulcer symptoms and their relief were recorded by patients, along with data on cigarette, alcohol, and drug intake. Endoscopy was performed after 4 weeks to assess healing. By 4 weeks, 18 of 26 patients taking tablets (69%) and 19 out of 25 patients taking liquid (76%), had healed (p = 0.82). Symptomatic improvement was similar with both tablets and liquid. Smoking and analgesic ingestion did not influence healing rate. We conclude that C.B.S. tablets and liquid are equally effective in healing duodenal ulcer.
一项针对51名门诊患者的双盲试验旨在比较片剂和液体制剂的枸橼酸铋钾（C.B.S.）在十二指肠溃疡愈合中的有效性。入选标准包括经内镜证实的十二指肠溃疡、症状持续时间超过4周以及无其他主要全身性疾病。患者服用C.B.S.片剂（每日4次，每次1片）或C.B.S.液剂（每日4次，每次5毫升），为期4周。患者记录溃疡症状及其缓解情况，以及吸烟、饮酒和药物摄入的数据。4周后进行内镜检查以评估愈合情况。到4周时，服用片剂的26名患者中有18名（69%）愈合，服用液剂的25名患者中有19名（76%）愈合（p = 0.82）。片剂和液剂的症状改善情况相似。吸烟和服用镇痛药不影响愈合率。我们得出结论，C.B.S.片剂和液剂在十二指肠溃疡愈合方面同样有效。
