神经营养蛋白在培养中调节肌肉乙酰胆碱酯酶。
Neurotrophic protein regulates muscle acetylcholinesterase in culture.
作者信息
Oh T H, Markelonis G J
出版信息
Science. 1978 Apr 21;200(4339):337-9. doi: 10.1126/science.635593.
PMID:635593
Abstract
Skeletal muscles lose acetylcholinesterase in culture as a result of denervation. A protein fraction isolated from peripheral nerves maintained the level of acetylcholinesterase in cultures of aneural embryonic muscle or denervated adult chicken muscle. These results indicate that trophic regulation of muscle acetylcholinesterase might be mediated by a protein produced by nerves.
摘要
由于去神经支配，骨骼肌在培养过程中会失去乙酰胆碱酯酶。从周围神经分离出的一种蛋白质组分可维持无神经胚胎肌肉或去神经支配的成年鸡肌肉培养物中乙酰胆碱酯酶的水平。这些结果表明，肌肉乙酰胆碱酯酶的营养调节可能由神经产生的一种蛋白质介导。
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