Dourson M L, Stara J F
Regul Toxicol Pharmacol. 1983 Sep;3(3):224-38. doi: 10.1016/0273-2300(83)90030-2.
A synthesis of available literature on uncertainty (safety) factors which are used to estimate acceptable daily intakes (ADIs) for toxicants is presented. This synthesis reveals reasonable qualitative biological premises, as well as specific biological data that support both the use and choice of these factors. A suggestion is made in order to derive a range of ADI. Research needs in various areas of uncertainty are also identified.
本文对用于估算毒物每日允许摄入量（ADI）的不确定性（安全）因素的现有文献进行了综述。该综述揭示了合理的定性生物学前提以及支持这些因素使用和选择的具体生物学数据。文中提出了推导ADI范围的建议。还确定了不确定性各领域的研究需求。
