氯喹耐药恶性疟原虫：兔血清和孵育时间对体内耐药性体外（微量技术）预测的影响。
Chloroquine resistant Plasmodium falciparum: effect of rabbit serum and incubation time on the in vitro (microtechnique) prediction of in vivo resistance.
作者信息
Smrkovski L L, Alcantara A, Buck R L, Sy N E, Rodriguez C S, Macalagay P S, Uylangco C B
出版信息
Southeast Asian J Trop Med Public Health. 1983 Jun;14(2):228-34.
A study of chloroquine resistance of 54 isolates of Plasmodium falciparum is reported. Sixty-four percent of the isolates tested produced schizonts in vitro (micro-technique), whereas the remaining 36 percent did not. The accuracy of the in vitro test to predict in vivo resistance was increased when the primary parasite isolates were cultured in the presence of rabbit serum and when the cultures were allowed to incubate for more than 48 hours. Thirteen isolates of P. falciparum that showed in vitro resistance were confirmed in vivo resistant. Eleven of these cases were identified as R-I and two as R-II. Only one case of in vivo resistance (R-II) was observed among the 19 isolates that failed to produce schizonts in vitro.
报告了一项对54株恶性疟原虫氯喹耐药性的研究。所检测的分离株中有64%在体外（微技术）产生了裂殖体，而其余36%则未产生。当原代寄生虫分离株在兔血清存在的情况下培养，并且培养物孵育超过48小时时，体外试验预测体内耐药性的准确性会提高。13株在体外显示耐药性的恶性疟原虫分离株在体内被证实具有耐药性。其中11例被鉴定为R-I型，2例为R-II型。在19株体外未产生裂殖体的分离株中，仅观察到1例体内耐药性（R-II型）。
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