磷霉素可使携带磷霉素抗性质粒的大肠杆菌细胞中的靶酶失活。
Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid.
作者信息
León J, García-Lobo J M, Ortiz J M
出版信息
Antimicrob Agents Chemother. 1983 Aug;24(2):276-8. doi: 10.1128/AAC.24.2.276.
Abstract
The target enzyme for fosfomycin antibiotic action, enolpyruvyl transferase, was synthesized in similar amounts and with similar kinetic and inhibition constants for phosphoenolpyruvate and fosfomycin, respectively, by an Escherichia coli strain containing the fosfomycin resistance plasmid pOU900 and by plasmid-free strains. Neither phosphoenolpyruvate level nor murein synthesis was altered by pOU900.
摘要
磷霉素抗生素作用的靶酶烯醇丙酮酸转移酶，由含有磷霉素抗性质粒pOU900的大肠杆菌菌株和无质粒菌株分别以相似的量合成，且对磷酸烯醇丙酮酸和磷霉素分别具有相似的动力学常数和抑制常数。pOU900既未改变磷酸烯醇丙酮酸水平，也未改变胞壁质合成。
相似文献
1
Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid.磷霉素可使携带磷霉素抗性质粒的大肠杆菌细胞中的靶酶失活。
Antimicrob Agents Chemother. 1983 Aug;24(2):276-8. doi: 10.1128/AAC.24.2.276.
2
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.大肠杆菌细胞壁生物合成酶UDP-葡萄糖胺烯醇丙酮酸转移酶（MurA）中半胱氨酸115突变为天冬氨酸的特性，该突变使细菌对抗生素磷霉素的失活产生抗性。
Biochemistry. 1996 Apr 16;35(15):4923-8. doi: 10.1021/bi952937w.
3
Identification of a novel UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Vibrio fischeri that confers high fosfomycin resistance in Escherichia coli.从费氏弧菌中鉴定出一种新型的尿苷二磷酸-N-乙酰葡糖胺烯醇丙酮酸转移酶（MurA），该酶可使大肠杆菌对磷霉素产生高度抗性。
Arch Microbiol. 2009 May;191(5):425-9. doi: 10.1007/s00203-009-0468-9. Epub 2009 Mar 11.
4
Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.磷霉素抗性质粒不影响磷霉素转运进入大肠杆菌。
Antimicrob Agents Chemother. 1982 Apr;21(4):608-12. doi: 10.1128/AAC.21.4.608.
5
Identification of a novel fosfomycin-resistant UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from a soil metagenome.从土壤宏基因组中鉴定一种新型磷霉素耐药 UDP-N-乙酰葡糖胺烯醇式丙酮酸转移酶（MurA）。
Biotechnol Lett. 2013 Feb;35(2):273-8. doi: 10.1007/s10529-012-1074-5. Epub 2012 Nov 10.
6
Differential antibacterial properties of the MurA inhibitors terreic acid and fosfomycin.MurA 抑制剂土霉素酸和磷霉素的抑菌特性差异。
J Basic Microbiol. 2014 Apr;54(4):322-6. doi: 10.1002/jobm.201200617. Epub 2013 May 20.
7
How is fosfomycin resistance developed in Escherichia coli?大肠杆菌中磷霉素耐药性是如何产生的？
Future Microbiol. 2018 Dec;13:1693-1696. doi: 10.2217/fmb-2018-0294. Epub 2018 Dec 11.
8
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin.UDP-N-乙酰葡糖胺烯醇丙酮酸转移酶的结构，该酶是细菌肽聚糖合成所必需的一种酶，与底物UDP-N-乙酰葡糖胺和药物磷霉素形成复合物。
Structure. 1996 Dec 15;4(12):1465-74. doi: 10.1016/s0969-2126(96)00153-0.
9
Emergence of fosfomycin-resistant isolates of Shiga-like toxin-producing Escherichia coli O26.产志贺毒素大肠杆菌O26磷霉素耐药菌株的出现。
Antimicrob Agents Chemother. 1999 Apr;43(4):789-93. doi: 10.1128/AAC.43.4.789.
10
Characterization of fosA5, a new plasmid-mediated fosfomycin resistance gene in Escherichia coli.大肠杆菌中新型质粒介导的磷霉素抗性基因fosA5的特性分析。
Lett Appl Microbiol. 2015 Mar;60(3):259-64. doi: 10.1111/lam.12366. Epub 2014 Dec 21.
引用本文的文献
1
Plasmid-mediated fosfomycin resistance is due to enzymatic modification of the antibiotic.质粒介导的磷霉素耐药性是由于抗生素的酶促修饰所致。
Antimicrob Agents Chemother. 1985 Jul;28(1):163-4. doi: 10.1128/AAC.28.1.163.
2
Plasmid-encoded fosfomycin resistance.质粒编码的磷霉素耐药性
Antimicrob Agents Chemother. 1991 May;35(5):791-5. doi: 10.1128/AAC.35.5.791.
本文引用的文献
1
Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.磷霉素抗性质粒不影响磷霉素转运进入大肠杆菌。
Antimicrob Agents Chemother. 1982 Apr;21(4):608-12. doi: 10.1128/AAC.21.4.608.
2
Tn292l, a transposon encoding fosfomycin resistance.Tn292l，一种编码磷霉素抗性的转座子。
J Bacteriol. 1982 Jul;151(1):477-9. doi: 10.1128/jb.151.1.477-479.1982.
3
Induction of cell lysis in Escherichia coli: cooperative effect of nocardicin A and mecillinam.大肠杆菌中细胞裂解的诱导：诺卡菌素A和美西林的协同作用。
Antimicrob Agents Chemother. 1982 Feb;21(2):195-200. doi: 10.1128/AAC.21.2.195.
4
A stable enzyme-phosphoenolpyruvate intermediate in the synthesis of uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-O-enolpyruvyl ether.
Biochemistry. 1973 Mar 27;12(7):1364-74. doi: 10.1021/bi00731a017.
5
The hexose phosphate transport system of Escherichia coli.
Adv Enzymol Relat Areas Mol Biol. 1976;44:237-59. doi: 10.1002/9780470122891.ch7.
Zotero 插件