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Tn292l,一种编码磷霉素抗性的转座子。

Tn292l, a transposon encoding fosfomycin resistance.

作者信息

García-Lobo J M, Ortiz J M

出版信息

J Bacteriol. 1982 Jul;151(1):477-9. doi: 10.1128/jb.151.1.477-479.1982.

DOI:10.1128/jb.151.1.477-479.1982
PMID:6282810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC220265/
Abstract

The determinant of resistance to fosfomycin of the Serratia marcescens plasmid pOU900 was transposed into the plasmid ColE1 and into the plasmid RP4 in the absence of the RecA function of the host. In each case, the acquisition of fosfomycin resistance was correlated with the presence of a discrete piece of DNA, uniform in size and in restriction pattern, This new, 7.5-megadalton transposable element encoding resistance to fosfomycin has been called Tn2921. A preliminary map of the transposon is presented.

摘要

粘质沙雷氏菌质粒pOU900对磷霉素耐药性的决定因子在宿主RecA功能缺失的情况下转座到质粒ColE1和质粒RP4中。在每种情况下,磷霉素耐药性的获得都与一段大小和限制酶切图谱均一的离散DNA片段的存在相关。这个编码磷霉素耐药性的新的7.5兆道尔顿转座元件被称为Tn2921。文中给出了该转座子的初步图谱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/220265/64be3cd0d81a/jbacter00254-0488-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/220265/64be3cd0d81a/jbacter00254-0488-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e910/220265/64be3cd0d81a/jbacter00254-0488-a.jpg

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本文引用的文献

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Antimicrob Agents Chemother. 1980 Aug;18(2):215-9. doi: 10.1128/AAC.18.2.215.
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The mechanism of action of fosfomycin (phosphonomycin).磷霉素的作用机制。
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Charactertization of spontaneous fosfomycin (phosphonomycin)-resistant cells of Escherichia coli B in vitro.体外大肠杆菌B自发磷霉素抗性细胞的特性研究。
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