Poulsen K, Jacobsen J
Clin Exp Hypertens A. 1983;5(7-8):969-73. doi: 10.3109/10641968309048835.
The biochemistry of the renin-angiotensin system in aggressive mice may question a simple role of the system in blood pressure regulation. When male mice are fighting, their plasma concentration of active renin may rise several hundred fold without affecting blood pressure. The source of this renin is secretion to the blood from the submaxillary gland and the kidneys, but also small salivary glands may contribute. A further source may be salivary renin transferred by bites from one animal to another, as indicated by recent experiments. The renin concentration in saliva of an aggressor during a fight reaches values of 6000 GU/ml (15 mg/ml). The huge increase in plasma renin is caused by fully enzymatic active 40 000 Mw renin. Preliminary data, collected in order to study whether this renin is active also in vivo, show the following: Inactive renin is present in a small invariable concentration. The renin substrate is consumed in vivo and the measured generation rate of angiotensin is that expected from the renin and substrate concentration. The data seem to indicate that the high concentration of aggression-provoked renin is active in vivo. It is unknown how the mouse protects its blood pressure against this hyperactive pressor system.
攻击性小鼠体内肾素 - 血管紧张素系统的生物化学特性可能对该系统在血压调节中的简单作用提出质疑。当雄性小鼠打架时，其活性肾素的血浆浓度可能会升高数百倍，而血压却不受影响。这种肾素的来源是颌下腺和肾脏向血液中的分泌，但小唾液腺也可能有贡献。如最近的实验所示，另一个来源可能是通过咬伤从一只动物转移到另一只动物的唾液肾素。打架时攻击者唾液中的肾素浓度达到6000 GU/ml（15 mg/ml）。血浆肾素的大幅增加是由完全具有酶活性的40000 Mw肾素引起的。为研究这种肾素在体内是否也有活性而收集的初步数据如下：无活性肾素以小且恒定的浓度存在。肾素底物在体内被消耗，所测得的血管紧张素生成速率与肾素和底物浓度所预期的一致。数据似乎表明，由攻击引发的高浓度肾素在体内具有活性。尚不清楚小鼠如何保护其血压免受这种过度活跃的升压系统的影响。
