Klipstein F A, Engert R F, Houghten R A
Infect Immun. 1983 Nov;42(2):838-41. doi: 10.1128/iai.42.2.838-841.1983.
Klebsiella pneumoniae heat-stable enterotoxin was purified to apparent homogenicity by the same techniques used to purify Escherichia coli heat-stable enterotoxin. The two toxins had the same potency in the suckling mouse assay and showed immunological cross-reactivity in enzyme-linked immunosorbent assay, neutralization of secretory activity by specific hyperimmune antisera, and protection against active challenge in rats immunized with a vaccine containing synthetically produced E. coli heat-stable enterotoxin.
肺炎克雷伯菌热稳定肠毒素通过用于纯化大肠杆菌热稳定肠毒素的相同技术被纯化至表观同质性。这两种毒素在乳鼠试验中具有相同的效力，并且在酶联免疫吸附测定、用特异性超免疫抗血清中和分泌活性以及在用含有合成产生的大肠杆菌热稳定肠毒素的疫苗免疫的大鼠中抵御活性攻击方面表现出免疫交叉反应性。
