Viktorova L S, Verbina N M
Mikrobiologiia. 1983 Jul-Aug;52(4):615-9.
Sulfochlorantine containing active chlorine was shown to produce a general toxic action inactivating a number of Escherichia coli enzyme systems involved in protein biosynthesis. DNA synthesis catalysed by calf thymus DNA polymerase alpha was repressed by 50% and the synthesis of aminoacyl-tRNA catalysed by aminoacyl-tRNA synthetases was repressed by 70% in the cell-free systems at the lethal concentration of the bactericide (0.01% and higher). Sulfochlorantine produced the strongest inhibiting action on the ribosomal step of protein biosynthesis, inhibiting the poly(U)-directed polyphenylalanine formation by 95% at the sublethal concentration of the bactericide (0.005%).
含活性氯的磺胺氯胺被证明会产生一般毒性作用，使参与蛋白质生物合成的多种大肠杆菌酶系统失活。在无细胞系统中，当杀菌剂达到致死浓度（0.01%及更高）时，小牛胸腺DNA聚合酶α催化的DNA合成被抑制50%，氨酰-tRNA合成酶催化的氨酰-tRNA合成被抑制70%。磺胺氯胺对蛋白质生物合成的核糖体步骤产生最强的抑制作用，在杀菌剂亚致死浓度（0.005%）下，抑制多聚（U）指导的聚苯丙氨酸形成达95%。
