Dolak L A, Castle T M, Hannon B R, Argoudelis A D, Reusser F
J Antibiot (Tokyo). 1983 Nov;36(11):1425-30. doi: 10.7164/antibiotics.36.1425.
The new antifungal agent nitrosofungin was isolated in high yields from a mixed culture of two organisms consisting of a bacterium of the genus Alcaligenes (UC 9152) and Streptomyces plicatus UC 8272. The bacterium produces the agent, the streptomycete enhances the production by providing a precursor or an inducer. Nitrosofungin in high concentrations inhibits a broad variety of pathogenic fungi in vitro. The agent is relatively non-toxic in small laboratory animals and high blood levels are obtained after either oral or systemic administration. Nitrosofungin is only the second N-nitrosohydroxylamine isolated from microbial sources to date. It has been identified as 2-N-nitrosohydroxylamino-1-propanol, an acidic and highly water-soluble compound.
新型抗真菌剂亚硝基菌素是从由产碱杆菌属（UC 9152）细菌和褶皱链霉菌UC 8272组成的两种微生物混合培养物中高产分离得到的。该细菌产生该药剂，链霉菌通过提供前体或诱导剂来提高产量。高浓度的亚硝基菌素在体外可抑制多种致病真菌。该药剂在小型实验动物中相对无毒，口服或全身给药后可获得较高的血药浓度。亚硝基菌素是迄今为止从微生物来源分离得到的第二种N-亚硝基羟胺。它已被鉴定为2-N-亚硝基羟氨基-1-丙醇，一种酸性且高度水溶性的化合物。
