一些免疫化学数据对多发性硬化症病毒病因学的意义。
Significance of some immunochemical data for the viral pathogeny of multiple sclerosis.
作者信息
Cernescu C, Ghyka G, Verdeş F, Sorodoc Y
出版信息
Virologie. 1978 Jan-Mar;29(1):15-22.
Cerebrospinal fluid (CSF) samples from 124 patients with different neurological diseases (35 having an ascertained diagnosis of multiple sclerosis (MS) and 20--of subacute sclerosing panencephalitis (SSPE)) were investigated by immunoelectrophoresis. The correlation between the "secretory" immunoelectrophoretic pattern of CSF proteins in MS and SSPE patients and the incidence of antimeasles HI antibodies in the CSF is analysed. The results point to a different pathogenic significance of the presence of antimeasles antibodies : a) persistent measles virus infection in SSPE and b) a particular genetic constitution, coincident with a hyperreactivity to measles virus, in MS.
对124例患有不同神经系统疾病的患者（35例确诊为多发性硬化症（MS），20例为亚急性硬化性全脑炎（SSPE））的脑脊液（CSF）样本进行了免疫电泳研究。分析了MS和SSPE患者脑脊液蛋白“分泌性”免疫电泳图谱与脑脊液中抗麻疹血凝抑制（HI）抗体发生率之间的相关性。结果表明抗麻疹抗体的存在具有不同的致病意义：a）SSPE中持续存在麻疹病毒感染；b）MS中存在特定的基因构成，同时伴有对麻疹病毒的高反应性。
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