Derrick C W, Reilly K
Postgrad Med J. 1983;59 Suppl 5:43-6.
Cephalexin remains an effective and highly useful antibiotic for the treatment of streptococcal and staphylococcal skin infections. Twelve years of experience have not diminished its efficacy, and cure rates of 90% or higher continue to be achieved. Its resistance to degradation by gastric acid and its uniform absorption ensure its bioavailability, and its efficacy in twice-daily dosages enhances medication compliance. The suspension formulation is well accepted by young children, and side effects have generally been mild and infrequent. Cephalexin is comparable to erythromycin, clindamycin, dicloxacillin, cloxacillin, and other cephalosporins in the treatment of streptococcal and staphylococcal infections. Because many of these antibiotics are similar in their efficacy, palatability, and adverse reactions, cost factors may play an important role in choosing one over the other. Penicillin remains the drug of choice for streptococcal skin infections. If the cure rates of the mixed streptococcal-staphylococcal lesions continue to decrease with penicillin, cephalexin and the other alternative antibiotics may assume a more important role in the primary treatment of these infections in the future.
头孢氨苄仍然是治疗链球菌和葡萄球菌皮肤感染的一种有效且非常有用的抗生素。十二年的使用经验并未降低其疗效，治愈率仍能达到90%或更高。它对胃酸降解具有抗性且吸收均匀，确保了其生物利用度，每日两次给药的疗效提高了用药依从性。混悬液剂型很受幼儿欢迎，副作用通常轻微且不常见。在治疗链球菌和葡萄球菌感染方面，头孢氨苄与红霉素、克林霉素、双氯西林、氯唑西林及其他头孢菌素相当。由于这些抗生素中的许多在疗效、适口性和不良反应方面相似，成本因素在选择使用哪种药物时可能起重要作用。青霉素仍然是链球菌皮肤感染的首选药物。如果青霉素治疗混合性链球菌 - 葡萄球菌皮损的治愈率持续下降，头孢氨苄和其他替代抗生素在未来这些感染的初始治疗中可能会发挥更重要的作用。
