Riblet L A, Eison A S, Eison M S, Newton R E, Taylor D P, Temple D L
Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):663-8. doi: 10.1016/0278-5846(83)90042-8.
Buspirone HCl (Buspar) is a novel anxiolytic agent unrelated to the benzodiazepines or other psychotherapeutic agents. Animal studies support an anxioselective profile, i.e. relief of anxiety without sedation, muscle relaxation or anticonvulsant activity. Double-blind clinical studies show buspirone to be effective in the treatment of anxiety and anxiety in the presence of depression. The effects of buspirone on psychomotor function, physical dependence and abuse potential tests are similar to those seen with placebo treatments. Mechanism of action studies indicate activity in a variety of neuronal systems.
盐酸丁螺环酮（布斯帕）是一种新型抗焦虑药，与苯二氮䓬类或其他心理治疗药物无关。动物研究支持其具有抗焦虑选择性，即缓解焦虑但无镇静、肌肉松弛或抗惊厥活性。双盲临床研究表明，丁螺环酮在治疗焦虑症以及伴有抑郁的焦虑症方面有效。丁螺环酮对精神运动功能、身体依赖性和滥用可能性测试的影响与安慰剂治疗相似。作用机制研究表明其在多种神经元系统中具有活性。
