Heimdahl A, Gahrton G, Groth C G, Lundgren G, Lönnquist B, Ringden O, Nord C E
Scand J Infect Dis. 1984;16(1):51-60. doi: 10.3109/00365548409068409.
14 patients undergoing bone marrow transplantation were studied regarding the oral and faecal microflora. Seven patients were given a multidrug regimen, directed against aerobic gram-negative rods and fungi, for local decontamination of the oral cavity and gastrointestinal tract. Seven other patients served as controls. The decontamination regimen was found to decrease the numbers of fungi in the oral cavity and to protect from new colonization. In the gastrointestinal tract aerobic gram-negative rods were eliminated in all patients and new colonization with acquired microorganisms was not observed even when the indigenous anaerobic flora had been disturbed by parenteral antibiotics. In the control group aerobic gram-negative rods and fungi were isolated from all patients during the observation period.
对14例接受骨髓移植的患者的口腔和粪便微生物群进行了研究。7例患者接受了针对需氧革兰氏阴性杆菌和真菌的多药方案，用于口腔和胃肠道的局部净化。另外7例患者作为对照。发现净化方案可减少口腔中的真菌数量并防止新的定植。在胃肠道中，所有患者的需氧革兰氏阴性杆菌均被清除，即使肠道内源性厌氧菌群受到胃肠外抗生素的干扰，也未观察到获得性微生物的新定植。在对照组中，在观察期内所有患者均分离出需氧革兰氏阴性杆菌和真菌。
