Roggendorf W, Brock M, Görge H H, Curio G
J Neurosurg. 1984 Mar;60(3):518-22. doi: 10.3171/jns.1984.60.3.0518.
Lumbar disc tissue from 10 patients who had previously undergone chemonucleolysis without success was studied by light and scanning electron microscopy. Seven patients had a sequestrated disc; three had large protrusions. As a control, material from 10 patients subjected to disc surgery without previous chemonucleolysis was studied in the same way. The control discs revealed the characteristic signs of degeneration: alteration of the collagen, microcystic areas, and giant chondromas. Changes following chemonucleolysis were restricted exclusively to the ground substance and characterized by a marked loss of basophilia in the cartilage matrix. There was no involvement of the anulus fibrosus, cartilage plate, or bone. Following chymopapain administration, scanning electron microscopy showed a naked collagen network devoid of ground substance.
对10例先前接受化学溶核术但未成功的患者的腰椎间盘组织进行了光镜和扫描电镜研究。7例患者有椎间盘游离；3例有巨大突出。作为对照，对10例未接受过化学溶核术而接受椎间盘手术的患者的材料进行了同样的研究。对照椎间盘显示出典型的退变征象：胶原改变、微囊区和巨大软骨瘤。化学溶核术后的变化仅局限于基质，其特征是软骨基质中嗜碱性明显丧失。纤维环、软骨板或骨未受累。注射木瓜凝乳蛋白酶后，扫描电镜显示裸露的胶原网络，无基质。
