Komissarenko V P, Gordienko V M, Turchin I S, Lazareva N P
Tsitol Genet. 1984 Jan-Feb;18(1):9-13.
B-, A- and D-insulocytes have been identified by electron microscopy as early as the first 24 h of cultivation. After 3-5 days of the culture growth the B-cells displayed development of the endoplasm net, hypertrophy of the Golgi apparatus and an increased number of vacuoles and granule-like formations. When the time of cultivation was prolonged (7-12 days), in the B-cell cytoplasm there appeared signs of increasing dystrophic changes indicative of cell ageing.
早在培养的最初24小时，通过电子显微镜就已鉴定出B -、A -和D -胰岛细胞。培养生长3 - 5天后，B细胞内质网发育、高尔基体肥大，空泡和颗粒样结构数量增加。当培养时间延长（7 - 12天）时，B细胞细胞质中出现营养不良变化加剧的迹象，表明细胞老化。
