内毒素血症作为免疫抑制患者发热的一个原因。
Endotoxaemia as a cause of fever in immunosuppressed patients.
作者信息
Harris R I, Stone P C, Evans G R, Stuart J
出版信息
J Clin Pathol. 1984 Apr;37(4):467-70. doi: 10.1136/jcp.37.4.467.
Abstract
Using a recently developed chromogenic substrate assay sensitive to 10 pg/ml Escherichia coli endotoxin in plasma, systemic endotoxaemia was found in 52% of 21 episodes of fever in patients with a haematological malignancy who were infected. Endotoxaemia was also found in 27% of 22 episodes of fever of unknown origin. In 45 afebrile patients neither neutropenia nor cytotoxic chemotherapy was a cause of endotoxaemia. Passage of endotoxin from portal blood into the systemic circulation can contribute to unexplained fever in immunosuppressed patients.
摘要
使用一种最近开发的对血浆中10 pg/ml大肠杆菌内毒素敏感的显色底物测定法，发现在21例感染的血液系统恶性肿瘤患者的发热发作中，52%存在全身性内毒素血症。在22例不明原因发热发作中，27%也发现了内毒素血症。在45例无发热患者中，中性粒细胞减少和细胞毒性化疗均不是内毒素血症的原因。内毒素从门静脉血进入体循环可能导致免疫抑制患者出现不明原因发热。
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Portal venous and systemic endotoxaemia in patients without liver disease and systemic endotoxaemia in patients with cirrhosis.无肝脏疾病患者的门静脉和全身内毒素血症以及肝硬化患者的全身内毒素血症。
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