Mertz G, Corey L
Urol Clin North Am. 1984 Feb;11(1):103-19.
With the decline in prevalence of childhood-acquired oral-labial herpes simplex type 1 infections in some populations and the increasing incidence of genital herpes infections in adults, clinicians are more likely to see patients with severe primary, first-episode genital herpes infections. Complications of these primary infections may include aseptic meningitis and urine retention secondary to sacral radiculopathy or autonomic dysfunction. Presented are the clinical course of first-episode and recurrent infections, complications, diagnostic laboratory methods, and results of controlled clinical trials evaluating the efficacy of topical, intravenous, and oral preparations of acyclovir.
随着某些人群中儿童期获得的口腔-唇单纯疱疹病毒1型感染患病率的下降以及成人中生殖器疱疹感染发病率的上升，临床医生更有可能见到患有严重原发性、初发性生殖器疱疹感染的患者。这些原发性感染的并发症可能包括无菌性脑膜炎以及继发于骶神经根病或自主神经功能障碍的尿潴留。本文介绍了初发性和复发性感染的临床过程、并发症、诊断实验室方法以及评估阿昔洛韦局部、静脉和口服制剂疗效的对照临床试验结果。
