Bücking J, Schwartau M
Dtsch Med Wochenschr. 1984 Apr 27;109(17):671-3. doi: 10.1055/s-2008-1069252.
Threshold increase, regularly observed after implantation of pacemakers, leads to increased current consumption and is the decisive factor in determining duration of pacemaker function. Local liberation of dexamethasone at the catheter tip inhibits reactive scar formation at this point. Studies on ten patients showed that with such a steroid-containing catheter thresholds even four weeks after implantation are below 0.07 ms at 2.5 or 1.25 V. Intraoperatively measured intracardiac R-wave potentials increased from 8.4 to 12.5 mV.
起搏器植入后经常观察到的阈值升高会导致电流消耗增加,并且是决定起搏器功能持续时间的决定性因素。地塞米松在导管尖端的局部释放可抑制此处的反应性瘢痕形成。对10名患者的研究表明,使用这种含类固醇的导管,即使在植入后四周,在2.5伏或1.25伏时阈值仍低于0.07毫秒。术中测量的心内R波电位从8.4毫伏增加到12.5毫伏。