Philipson A
Am J Obstet Gynecol. 1978 Mar 15;130(6):674-83. doi: 10.1016/0002-9378(78)90327-7.
A single dose of ampicillin as been reported to produce lower plasma levels in pregnant than in nonpregnant women. In the present study plasma and urine levels oa ampicillin were studied in pregnant women following administration of multiple oral doses as well as single doses of 0.35 Gm. of pivampicillin and 0.5, 1.0, and 2.0 Gm. of ampicillin. Assays for levels of ampicillin were performed by means of a disc-agar-diffusion method. Multiple doses of ampicillin resulted in plasma levels and recovery in urine similar to those after a single dose. Mean plasma levels were low. A dose of 1.0 Gm. of ampicillin resulted in plasma levels in pregnant women comparable to those reported earlier by us in nonpregnant women following a dose of 0.5 Gm. A dose of 0.35 Gm. of pivampicillin resulted in plasma levels considerably lower than those reported by others in nonpregnant subjects, but plasma levels and recovery in urine were as high as those produced in pregnant women by 0.5 Gm. of ampicillin.
据报道，单剂量氨苄西林在孕妇体内产生的血浆水平低于非孕妇。在本研究中，对孕妇口服多剂量以及单剂量0.35克匹氨西林和0.5克、1.0克及2.0克氨苄西林后的血浆和尿液水平进行了研究。采用纸片琼脂扩散法测定氨苄西林水平。多剂量氨苄西林导致的血浆水平和尿回收率与单剂量后的情况相似。平均血浆水平较低。1.0克氨苄西林剂量使孕妇的血浆水平与我们之前报道的非孕妇服用0.5克剂量后的血浆水平相当。0.35克匹氨西林剂量导致的血浆水平远低于其他研究中报道的非孕妇受试者的血浆水平，但血浆水平和尿回收率与孕妇服用0.5克氨苄西林后的水平一样高。
