Ninomiya K, Yoshimoto T, Hasegawa Y
Jpn J Antibiot. 1984 Jan;37(1):14-7.
Ceftazidime ( CAZ ) exhibited in vitro activity greater than cefoperazone, cefotiam, cefmetazole and cefazolin and almost equal to cefotaxime (CTX), ceftizoxime (CZX) and latamoxef ( LMOX ) against E. coli and K. pneumoniae isolated from obstetrical or gynecological infections excluding urinary tract infections. This drug demonstrated less activity than other 6 cephems against B. fragilis. Against anaerobic Gram-positive cocci, it showed less activity than other cephems. CAZ was administered to 11 patients with obstetrical and gynecological infections. The clinical results of this drug were as follows; excellent in each 1 case of parametritis , wound infection and BARTHOLIN's abscess, good in 7 cases including 1 of puerperal fever, 2 of intrauterine infection and 4 of adnexitis, and poor in 1 cases of adnexitis. No side effects or haematobiochemical abnormalities were observed throughout this trial.
对于从产科或妇科感染（不包括尿路感染）中分离出的大肠杆菌和肺炎克雷伯菌，头孢他啶（CAZ）的体外活性高于头孢哌酮、头孢替安、头孢美唑和头孢唑林，几乎等同于头孢噻肟（CTX）、头孢唑肟（CZX）和拉氧头孢（LMOX）。该药物对脆弱拟杆菌的活性低于其他6种头孢菌素。对于厌氧革兰氏阳性球菌，它的活性也低于其他头孢菌素。11例患有产科和妇科感染的患者接受了CAZ治疗。该药物的临床结果如下：在1例子宫旁组织炎、伤口感染和巴氏腺脓肿中疗效极佳，在包括1例产褥热、2例子宫内感染和4例附件炎的7例中疗效良好，在1例附件炎中疗效较差。在整个试验过程中未观察到副作用或血液生化异常。
