Hirabayashi K, Okada E
Jpn J Antibiot. 1984 Jan;37(1):49-56.
Ceftazidime ( CAZ ) was studied for the transfer into intrapelvic tissues and for the clinical efficacy in the treatment of 20 cases of obstetrical and gynecological infections. Transfer into the tissues--Following intravenous 1 hour-drip infusion of 1 g, favourable transfer of CAZ into intrapelvic tissues was observed. The peak drug level of 50 approximately 66 micrograms/g was obtained at 5 approximately 36 minutes after completion of the administration. Clinical evaluation-- CAZ was administered at a daily dose of 2 approximately 4 g in 1 approximately 4 divided doses by intravenous drip infusion for 90 minutes. The subjects were patients with the following infections; pyometra (1), puerperal endometritis (3), parametritis (5), pelvioperitonitis (3), purulent lymphocytes (2), retroperitoneal abscess (1) and acute adnexitis (5). Clinical efficacy was; excellent in 15 cases, good in 3 cases and poor in 2 cases, with the overall efficacy rate of 90.0%. No notable side effects or abnormal laboratory findings were observed except for eruption in 1 case.
研究了头孢他啶（CAZ）向盆腔组织的转移情况以及其治疗20例妇产科感染的临床疗效。组织转移情况——静脉滴注1g，1小时滴完后，观察到CAZ向盆腔组织的良好转移。给药结束后5至36分钟，药物峰值水平达到50至66微克/克。临床评估——CAZ每日剂量为2至4g，分1至4次静脉滴注90分钟。受试者为患有以下感染的患者：积脓（1例）、产褥期子宫内膜炎（3例）、子宫旁组织炎（5例）、盆腔腹膜炎（3例）、脓性淋巴细胞炎（2例）、腹膜后脓肿（1例）和急性附件炎（5例）。临床疗效为：15例优，3例良，2例差，总有效率为90.0%。除1例出现皮疹外，未观察到明显的副作用或实验室检查异常。
