Ninomiya K, Yoshimoto T, Hasegawa Y
Jpn J Antibiot. 1984 Dec;37(12):2349-54.
In vitro activity of ceftriaxone (CTRX) was examined by agar plates dilution method against 398 strains isolated from the infections in the field of obstetrics and gynecology. MIC90 of CTRX against Staphylococcus (107 strains), E. coli (54 strains), K. pneumoniae (27 strains), Peptococcus and Peptostreptococcus (106 strains) and Bacteroides (104 strains) was more than 100 micrograms/ml, less than 0.20 micrograms/ml, less than 0.20 micrograms/ml, 6.25 micrograms/ml and 50 micrograms/ml, respectively. The concentrations of CTRX 16.9 hours after 1 hour intravenous drip infusion with 1 g were 46.2 micrograms/ml in the uterine artery, 48.0 micrograms/ml in the cubital vein, 11.0 micrograms/g in the endometrium, myometrium and cervix uteri, and 14.0 micrograms/g in the portio vaginalis. These concentrations of CTRX in the serum and uterine tissues were higher than the level required to inhibit 90% of the strains of E. coli, K. pneumoniae, and Peptococcus and Peptostreptococcus, isolated from the infections in the field of obstetrics and gynecology. Clinical efficacy of CTRX was evaluated in 7 cases consisting of 2 with puerperal fever and one each with puerperal intrauterine infection, intrauterine infection, pyometra, adnexitis and Bartholin's abscess. Clinical and bacteriological efficacies were seen in 6 and 4 cases, respectively. Neither noteworthy adverse reactions nor laboratory abnormalities were observed throughout this study.
采用琼脂平板稀释法检测了头孢曲松（CTRX）对从妇产科感染中分离出的398株菌株的体外活性。CTRX对葡萄球菌（107株）、大肠杆菌（54株）、肺炎克雷伯菌（27株）、消化球菌和消化链球菌（106株）以及拟杆菌（104株）的MIC90分别大于100微克/毫升、小于0.20微克/毫升、小于0.20微克/毫升、6.25微克/毫升和50微克/毫升。静脉滴注1克CTRX 1小时后16.9小时，子宫动脉中的浓度为46.2微克/毫升，肘静脉中的浓度为48.0微克/毫升，子宫内膜、子宫肌层和子宫颈中的浓度为11.0微克/克，阴道部中的浓度为14.0微克/克。血清和子宫组织中这些CTRX的浓度高于抑制从妇产科感染中分离出的90%的大肠杆菌、肺炎克雷伯菌、消化球菌和消化链球菌菌株所需的水平。对7例患者评估了CTRX的临床疗效，其中2例为产褥热，1例分别为产褥期子宫内感染、子宫内感染、子宫积脓、附件炎和巴氏腺脓肿。临床疗效和细菌学疗效分别见于6例和4例。在整个研究过程中未观察到明显的不良反应或实验室异常。
