Doko F
Jpn J Antibiot. 1984 Jan;37(1):57-62.
Basic and clinical studies on ceftazidime ( CAZ ) were carried out in the field of obstetrics and gynecology. The following results were obtained. The CAZ levels in the pelvic dead space exudate and serum were measured with passage of time in patients undergoing radical hysterectomy with pelvic lymphadenectomy for uterine cervical cancer after intravenous drip infusion of 1 g for 30 minutes. The serum level attained the peak of 87.0 micrograms/ml immediately after completion of the drip infusion and rapidly decreased thereafter. On the other hand, the pelvic dead space exudate level reached the peak of 27.9 micrograms/ml at 1 hour after completion of the drip infusion and gradually decreased thereafter, keeping higher levels than the serum levels. A total of 10 cases comprising 2 of adnexitis, 1 of pelvioperitonitis , 2 of pyometra and 5 of BARTHOLIN's abscess was treated with CAZ intravenous injection at a dose of 1 g twice daily for 5 approximately 6 days. The clinical efficacy was excellent in 1 case and good in 9 cases. Neither adverse reactions nor abnormal laboratory findings were observed in any of the cases.
在妇产科领域开展了头孢他啶（CAZ）的基础和临床研究。获得了以下结果。对因子宫颈癌行根治性子宫切除术加盆腔淋巴结清扫术的患者，在30分钟内静脉滴注1g后，随时间推移测量盆腔死腔渗出液和血清中的CAZ水平。滴注结束后血清水平立即达到峰值87.0微克/毫升，此后迅速下降。另一方面，盆腔死腔渗出液水平在滴注结束后1小时达到峰值27.9微克/毫升，此后逐渐下降，但一直高于血清水平。对总共10例患者进行了治疗，其中包括2例附件炎、1例盆腔腹膜炎、2例积脓和5例巴氏腺脓肿，采用CAZ静脉注射，剂量为每日2次，每次1g，持续约5至6天。临床疗效1例为优，9例为良。所有病例均未观察到不良反应或实验室检查异常。
