Kohara T, Matsui Y, Mizutani T, Noda M
Jpn J Antibiot. 1984 Jan;37(1):6-13.
Ceftazidime ( CAZ ), a new cephalosporin antibiotic, was studied for transference into tissues and clinical efficacy in the field of obstetrics and gynecology, and the following results were obtained: After one shot intravenous injection of CAZ 1 g, favourable transference of CAZ into uterine tissues was observed. While the mean serum level at 1 hour after the administration was 50.2 micrograms/ml, the levels in oviduct, ovary, endometrium, myometrium, cervix uteri and portio vaginalis were 25.9, 31.6, 24.9, 24.5, 34.2 micrograms/g and 40.6 micrograms/g, respectively. The half-life of CAZ in these tissues ranged from 1.16 to 1.65 hours while that in serum was 1.24 hours. The peak level in retroperitoneal space exudate (25.3 micrograms/ml) was obtained at 3 hours after one shot intravenous injection of CAZ 1 g. The level was still as high as 2.68 micrograms/ml even 12 hours after the administration. Out of 4 cases of obstetric and gynecological infections, 3 cases were assessable, CAZ was effective in these 3 assessable cases. Neither adverse effects nor abnormalities in laboratory findings due to CAZ were observed. Based on these results, CAZ is considered to be an highly effective antibiotic with good transference into uterine tissues and clinical efficacy in obstetric and gynecological infections.
头孢他啶（CAZ）是一种新型头孢菌素抗生素，我们对其在妇产科领域向组织中的转移情况及临床疗效进行了研究，获得了以下结果：静脉注射1g CAZ后，观察到CAZ能良好地转移至子宫组织。给药后1小时血清平均水平为50.2微克/毫升，而在输卵管、卵巢、子宫内膜、子宫肌层、子宫颈和阴道部的水平分别为25.9、31.6、24.9、24.5、34.2微克/克和40.6微克/克。CAZ在这些组织中的半衰期为1.16至1.65小时，而在血清中的半衰期为1.24小时。静脉注射1g CAZ后3小时，腹膜后间隙渗出液中的峰值水平为（25.3微克/毫升）。给药12小时后该水平仍高达2.68微克/毫升。在4例妇产科感染病例中，3例可评估，CAZ在这3例可评估病例中有效。未观察到因CAZ引起的不良反应或实验室检查异常。基于这些结果，CAZ被认为是一种高效抗生素，能良好地转移至子宫组织，对妇产科感染具有临床疗效。
