Rasmusson B
Acta Endocrinol (Copenh). 1984 May;106(1):112-5. doi: 10.1530/acta.0.1060112.
In 12 patients treated 2 to 58 months previously for medullary carcinoma of the thyroid, basal serum concentrations of calcitonin, gastrin, vasoactive intestinal polypeptide, glucagon, insulin, and pancreatic polypeptide were measured in search of any correlation between these and the clinical course of the disease. All patients had elevated serum calcitonin levels indicating present disease. One patient had increased serum concentrations of several hormones. Another had achlorhydria and high serum gastrin levels. No relationship between calcitonin and gastro-intestinal polypeptides was found in 11 patients. No correlations were found between serum levels of polypeptides and the occurrence of diarrhoea in 5 patients. It is concluded that gastro-intestinal polypeptides, which are produced by other apudomas, are not secreted in more than normal concentrations under basal conditions, by the majority of patients previously treated for medullary carcinoma of the thyroid.
对12例曾在2至58个月前接受过甲状腺髓样癌治疗的患者，测定了降钙素、胃泌素、血管活性肠肽、胰高血糖素、胰岛素和胰多肽的基础血清浓度，以探寻这些指标与疾病临床进程之间的任何相关性。所有患者血清降钙素水平均升高，提示疾病存在。1例患者多种激素的血清浓度升高。另1例患者有胃酸缺乏和高血清胃泌素水平。11例患者中未发现降钙素与胃肠多肽之间存在关联。5例患者中未发现多肽血清水平与腹泻发生之间存在相关性。得出的结论是，由其他APUD瘤产生的胃肠多肽，在基础条件下，大多数既往接受过甲状腺髓样癌治疗的患者不会分泌超过正常浓度的该类物质。
