Hinz J, Hautzinger H, Helling J, Schirren G, Sell G, Stahl K W, Kühne F W
Fortschr Med. 1984 May 10;102(18):523-8.
In 38 patients with chronic therapeutically resistant wounds, which, in 25 cases, had been existing for more than one year, Tetrachlorodecaoxide ( TCDO ) in a water solution containing glycerin was analyzed for its capacity to induce wound healing and compared in this respect to the standard in moist wound treatment, physiological sodium chloride. The results of the clinical trial demonstrate that the TCDO solution is significantly superior to physiological saline in local wound treatment regarding the degree of wound smear reduction, the formation of wound granulation tissue, the stimulation of epithelisation on the wound borders and the shrinking of the wound surface. The differences in therapeutic efficiency are so large that, in spite of the relatively small patient samples (21 + 17) it was possible to verify the superiority of a method for wound treatment in a randomized double blind clinical trial.
在38例慢性治疗抵抗性伤口患者中，其中25例伤口已存在一年以上，对含甘油水溶液中的四氯癸氧化物（TCDO）促进伤口愈合的能力进行了分析，并在这方面与湿性伤口治疗的标准——生理氯化钠溶液进行了比较。临床试验结果表明，在局部伤口治疗中，就伤口涂片减少程度、伤口肉芽组织形成、伤口边缘上皮化刺激以及伤口表面收缩而言，TCDO溶液明显优于生理盐水。治疗效果差异如此之大，以至于尽管患者样本相对较小（21 + 17），但仍有可能在随机双盲临床试验中验证一种伤口治疗方法的优越性。
