Yki-Järvinen H
J Clin Endocrinol Metab. 1984 Aug;59(2):350-3. doi: 10.1210/jcem-59-2-350.
Sensitivity to insulin (euglycemic clamp technique) and serum estradiol and progesterone levels were measured in seven normal nonobese women, aged 19-23 yr, during the follicular and luteal phases of the menstrual cycle. The mean serum progesterone level was 1.2 +/- 0.1 (+/- SE) nmol/liter in the follicular and 24.2 +/- 7.7 nmol/liter in the luteal phase (P less than 0.02). Mean plasma insulin was maintained at 84 +/- 6 and 86 +/- 3 mU/liter and mean plasma glucose at 4.6 +/- 0.1 and 4.6 +/- 0.1 mmol/liter during the insulin clamps in the follicular and luteal phases, respectively. The rate of glucose metabolism averaged 9.0 +/- 1.3 mg/kg X min in the follicular phase and 9.2 +/- 1.6 mg/kg X min (P = NS) during the luteal phase. These results indicate that insulin-mediated glucose metabolism, as determined by the euglycemic clamp technique, is unaffected by the phase of the menstrual cycle in normal women.
在7名年龄为19 - 23岁的正常非肥胖女性的月经周期卵泡期和黄体期，测量了她们对胰岛素的敏感性（正常血糖钳夹技术）以及血清雌二醇和孕酮水平。卵泡期血清孕酮平均水平为1.2±0.1（±标准误）nmol/升，黄体期为24.2±7.7 nmol/升（P<0.02）。在卵泡期和黄体期的胰岛素钳夹过程中，平均血浆胰岛素分别维持在84±6和86±3 mU/升，平均血浆葡萄糖分别维持在4.6±0.1和4.6±0.1 mmol/升。卵泡期葡萄糖代谢率平均为9.0±1.3 mg/kg×min，黄体期为9.2±1.6 mg/kg×min（P=无显著性差异）。这些结果表明，通过正常血糖钳夹技术测定，胰岛素介导的葡萄糖代谢在正常女性月经周期各阶段不受影响。
