Lenzhofer R, Moser K
Wien Med Wochenschr. 1984 Apr 30;134(8):199-202.
The new synthetic opioid Tramadol [1-(m-Methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexane-1-ol] was examined in 30 patients with different malignant diseases. An excellent or sufficient pain relief could be found in 86%. Only 14% of all patients did not respond. The analgetic effect throughout the day could be observed in most cases (92%) after the application of maximally 200 mg/die. Optimal or moderate subjective tolerance was found in 95% of all cases. Fatigue (65.8%), dryness of the mouth (68.4%), dizziness (14.3%) and perspiration (12.2%) were the main side effects. For this reason Tramadol can be recommended as a highly useful analgesic drug in the treatment of tumor induced pain.
新型合成阿片类药物曲马多[1-(间甲氧基苯基)-2-(二甲基氨基甲基)-环己醇-1-醇]在30例患有不同恶性疾病的患者中进行了研究。86%的患者疼痛得到了良好或充分缓解。所有患者中只有14%没有反应。在大多数情况下（92%），每日最大剂量应用200mg后，全天都能观察到镇痛效果。95%的病例发现有最佳或中度主观耐受性。疲劳（65.8%）、口干（68.4%）、头晕（14.3%）和出汗（12.2%）是主要的副作用。因此，曲马多可被推荐为治疗肿瘤引起疼痛的一种非常有用的镇痛药。
