Sogani P C, Vagaiwala M R, Whitmore W F
Cancer. 1984 Aug 15;54(4):744-50. doi: 10.1002/1097-0142(1984)54:4<744::aid-cncr2820540426>3.0.co;2-p.
Seventy-two patients with advanced prostatic carcinoma without previous endocrine therapy were treated with an oral nonsteroidal antiandrogen, flutamide. Sixty-three patients (87.5%) had a favorable response, and 9 patients showed no response. Flutamide appears to be a safe antiandrogen, usually effective in the management of patients with advanced prostatic cancer who have had no prior endocrine therapy.