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单克隆抗体揭示的人类B细胞淋巴瘤中的表面IgG亚类

Surface IgG subclasses in human B cell lymphomas as revealed by monoclonal antibodies.

作者信息

Smeland E B, Jefferis R, Godal T

出版信息

Clin Exp Immunol. 1984 Jul;57(1):163-70.

PMID:6378459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536097/
Abstract

IgG subclass expression on cells from lymph node biopsies of 17 sIgG positive B cell lymphomas has been studied. Subclass specific monoclonal antibodies were used in an immunoradiometric assay. Ten were also tested by immunofluorescence using a biotin-avidin system. Thirteen of the lymphomas expressed IgG only, while four co-expressed other Ig isotypes. Morphological investigations revealed that 14 lymphomas originated from germinal centre cells. IgG1 was found to be dominant subclass in 10 lymphomas, IgG3 in seven, IgG2 in one, while none expressed IgG4. Multiple IgG subclasses could not be detected in any of the lymphomas tested.

摘要

对17例表面免疫球蛋白G（sIgG）阳性B细胞淋巴瘤淋巴结活检细胞的IgG亚类表达情况进行了研究。在免疫放射分析中使用了亚类特异性单克隆抗体。其中10例还通过生物素-抗生物素蛋白系统的免疫荧光法进行了检测。13例淋巴瘤仅表达IgG，而4例同时表达其他Ig同种型。形态学研究显示，14例淋巴瘤起源于生发中心细胞。发现IgG1在10例淋巴瘤中为主要亚类，IgG3在7例中为主要亚类，IgG2在1例中为主要亚类，而无一例表达IgG4。在所检测的任何淋巴瘤中均未检测到多种IgG亚类。

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