桥本氏病中对破伤风类毒素免疫反应的调节缺陷。
Defective regulation of the immune response to tetanus toxoid in Hashimoto's disease.
作者信息
Fawcett J, Hutton C, Mclachlan S M, Clark F, Rees Smith B
出版信息
Immunology. 1984 Jul;52(3):525-8.
Abstract
The humoral immune response to tetanus toxoid has been studied in patients with Hashimoto's disease. Although the magnitude of the response was similar to that observed in normal subjects, the Hashimoto patients demonstrated an inability to regulate their levels of tetanus toxoid antibody. This apparent defect in the control of antibody synthesis may be an important factor in both the initiation and perpetuation of autoimmune thyroid disease.
摘要
已对桥本氏病患者针对破伤风类毒素的体液免疫反应进行了研究。尽管该反应的强度与在正常受试者中观察到的相似，但桥本氏病患者表现出无法调节其破伤风类毒素抗体水平。抗体合成控制方面的这一明显缺陷可能是自身免疫性甲状腺疾病发生和持续发展的一个重要因素。
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THE ANTIBODY RESPONSE TO TETANUS TOXOID IN PATIENTS WITH AUTO-IMMUNE THYROIDITIS.自身免疫性甲状腺炎患者对破伤风类毒素的抗体反应
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Lancet. 1959 Mar 28;1(7074):648-52. doi: 10.1016/s0140-6736(59)92401-8.
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N Engl J Med. 1956 Jan 5;254(1):6-12. doi: 10.1056/NEJM195601052540102.
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