血培养分离株中的氨基糖苷类耐药性。
Aminoglycoside resistance among blood culture isolates.
作者信息
Huovinen P, Grönroos P, Herva E, Katila M L, Klossner M L, Renkonen O V, Toivanen P
出版信息
J Clin Microbiol. 1984 Jul;20(1):65-9. doi: 10.1128/jcm.20.1.65-69.1984.
A total of 633 blood culture isolates were collected from 1981 to 1982 from seven major Finnish hospitals, including all university central hospitals. Susceptibility of the strains to gentamicin, tobramycin, amikacin, and netilmicin was determined by the Sensititre microtiter procedure. Resistance against any of these agents occurred in 1.3 to 6.5% of all strains studied. In the Turku University Central Hospital, an increased number of tobramycin- and gentamicin-resistant Staphylococcus epidermidis were found; the frequency of strains resistant to tobramycin was 57% and to gentamicin was 29% versus frequencies of 16 and 18%, respectively, which were observed in the other hospitals. An explanation for this might be a change in the use of aminoglycosides in the Turku University Central Hospital; within 3 years, 1979 to 1981, the consumption of tobramycin and amikacin had increased 330 and 290%, respectively, whereas the use of gentamicin had decreased to 24% of that in the beginning of the period. Resistance against tobramycin was mediated by enzymes APH(2")-AAC(6') and ANT(4').
1981年至1982年期间，从芬兰七家主要医院（包括所有大学中心医院）收集了共计633株血培养分离菌。采用Sensititre微量滴定法测定了这些菌株对庆大霉素、妥布霉素、阿米卡星和奈替米星的敏感性。在所研究的所有菌株中，对这些药物中任何一种产生耐药性的比例为1.3%至6.5%。在图尔库大学中心医院，发现耐妥布霉素和耐庆大霉素的表皮葡萄球菌数量增加；耐妥布霉素菌株的频率为57%，耐庆大霉素菌株的频率为29%，而在其他医院观察到的频率分别为16%和18%。对此的一种解释可能是图尔库大学中心医院氨基糖苷类药物的使用发生了变化；在1979年至1981年的3年内，妥布霉素和阿米卡星的消耗量分别增加了330%和290%，而庆大霉素的使用量降至该时期开始时的24%。对妥布霉素的耐药性由酶APH(2")-AAC(6')和ANT(4')介导。
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