Hietanen J, Reunala T
Scand J Dent Res. 1984 Jun;92(3):230-4. doi: 10.1111/j.1600-0722.1984.tb00884.x.
The oral mucosa of seven patients with dermatitis herpetiformis (DH) and one with linear IgA disease was studied. None of the patients with DH showed any macroscopic oral lesions, but direct immunofluorescence (IFL) examination of the buccal mucosa revealed granular IgA deposits in all patients. IgA deposits were found just below the basement membrane zone or slightly deeper in the connective tissue, i.e. a deposition pattern which is pathognomonic to DH. In three patients C3 deposits occurred in the same area as IgA. The patient with linear IgA disease had small white erythematous patches, nonspecific both clinically and histologically, on the palatal mucosa. However, oral IFL specimens showed heavy linear IgA deposits in the basement membrane zone, indicating that the oral mucosa is also involved in this rare disease. Buccal mucosal biopsy specimens were stained with four FITC-conjugated lectins (Ulex europaeus I, soybean, peanut and lentil). The lectin staining was similar in patients with DH and linear IgA disease and did not markedly differ from normal oral mucosa. Our results show that buccal IFL examination is a useful diagnostic aid in both DH and linear IgA disease.
对7例疱疹样皮炎（DH）患者和1例线状IgA病患者的口腔黏膜进行了研究。所有DH患者均未出现任何肉眼可见的口腔病变，但对颊黏膜进行直接免疫荧光（IFL）检查发现，所有患者均有颗粒状IgA沉积。IgA沉积见于基底膜带下方或结缔组织稍深处，即DH的特征性沉积模式。3例患者在与IgA相同的区域出现C3沉积。线状IgA病患者的腭黏膜有小的白色红斑，临床和组织学上均无特异性。然而，口腔IFL标本显示基底膜带有大量线状IgA沉积，表明口腔黏膜也参与了这种罕见疾病。用四种异硫氰酸荧光素（FITC）偶联的凝集素（荆豆凝集素I、大豆凝集素、花生凝集素和扁豆凝集素）对颊黏膜活检标本进行染色。DH患者和线状IgA病患者的凝集素染色相似，与正常口腔黏膜无明显差异。我们的结果表明，颊部IFL检查对DH和线状IgA病都是一种有用的诊断辅助手段。
