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1
In vivo activation of complement by IgA in a rat model.在大鼠模型中IgA对补体的体内激活作用。
Clin Exp Immunol. 1992 Jan;87(1):138-43. doi: 10.1111/j.1365-2249.1992.tb06427.x.
2
Activation of rat complement by soluble and insoluble rat IgA immune complexes.可溶性和不溶性大鼠IgA免疫复合物对大鼠补体的激活作用。
Eur J Immunol. 1988 Dec;18(12):1873-80. doi: 10.1002/eji.1830181202.
3
Complement enhances the clearance of large-sized soluble IgA aggregates in rats.
Eur J Immunol. 1991 May;21(5):1093-9. doi: 10.1002/eji.1830210502.
4
Complement depletion abolishes IgA-mediated glomerular inflammation in rats.补体耗竭可消除大鼠体内IgA介导的肾小球炎症。
Exp Nephrol. 1994 May-Jun;2(3):182-9.
5
Rat polymeric IgA binds C1q, but does not activate C1.大鼠多聚免疫球蛋白A能结合C1q，但不激活C1。
Mol Immunol. 1990 Sep;27(9):867-74. doi: 10.1016/0161-5890(90)90153-q.
6
Lack of complement activation by human IgA immune complexes.人IgA免疫复合物缺乏补体激活。
Clin Exp Immunol. 1988 Sep;73(3):479-83.
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Human complement activation via the alternative pathway on porcine endothelium initiated by IgA antibodies.由IgA抗体引发的猪内皮细胞上通过替代途径的人类补体激活。
Transplantation. 1995 Aug 15;60(3):287-91. doi: 10.1097/00007890-199508000-00014.
8
Combined glomerular deposition of polymeric rat IgA and IgG aggravates renal inflammation.聚合大鼠IgA和IgG的联合肾小球沉积会加重肾脏炎症。
Kidney Int. 2000 Jul;58(1):90-9. doi: 10.1046/j.1523-1755.2000.00144.x.
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Failure of IgA cold agglutinin to activate C.
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Nationwide epidemiological survey of childhood IgA vasculitis associated hospitalization in the USA.美国儿童IgA血管炎相关住院情况的全国性流行病学调查。
Clin Rheumatol. 2016 Nov;35(11):2749-2756. doi: 10.1007/s10067-016-3402-y. Epub 2016 Sep 5.
3
Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.血清低岩藻糖基化 IgA1 水平与 IgA 肾病肾小球 IgA 沉积不相关，这是基于免疫复合物组成的异质性。
BMC Nephrol. 2014 Jun 13;15:89. doi: 10.1186/1471-2369-15-89.
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Oral microbial ecology and the role of salivary immunoglobulin A.口腔微生物生态学与唾液免疫球蛋白A的作用
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Local and systemic activation of the whole complement cascade in human leukocytoclastic cutaneous vasculitis; C3d,g and terminal complement complex as sensitive markers.人白细胞破碎性皮肤血管炎中补体全级联反应的局部和全身激活；C3d、g和末端补体复合物作为敏感标志物
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6
Glycosylation of IgA is required for optimal activation of the alternative complement pathway by immune complexes.免疫复合物对替代补体途径的最佳激活需要IgA的糖基化。
Immunology. 1994 Jan;81(1):137-41.
7
An acute model for IgA-mediated glomerular inflammation in rats induced by monoclonal polymeric rat IgA antibodies.一种由单克隆聚合大鼠IgA抗体诱导的大鼠IgA介导的肾小球炎症急性模型。
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本文引用的文献

1
Activation of the guinea pig alternative complement pathway by mouse IgA immune complexes.小鼠IgA免疫复合物激活豚鼠替代补体途径。
J Exp Med. 1982 Jan 1;155(1):231-47. doi: 10.1084/jem.155.1.231.
2
Inherited deficiency of the third component of complement associated with recurrent pyogenic infections, circulating immune complexes, and vasculitis in a Dutch family.在一个荷兰家族中，遗传性补体第三成分缺乏与复发性化脓性感染、循环免疫复合物及血管炎相关。
Pediatrics. 1983 Jan;71(1):81-7.
3
Serum complement proteins in IgA nephropathy.IgA肾病中的血清补体蛋白。
Clin Nephrol. 1983 Nov;20(5):251-8.
4
IgA deposits in the oral mucosa of patients with dermatitis herpetiformis and linear IgA disease.疱疹样皮炎和线状IgA疾病患者口腔黏膜中的IgA沉积。
Scand J Dent Res. 1984 Jun;92(3):230-4. doi: 10.1111/j.1600-0722.1984.tb00884.x.
5
Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis.备解素在过敏性紫癜和特发性局灶性肾炎中的肾小球沉积。
Br Med J. 1973 Aug 11;3(5875):326-8. doi: 10.1136/bmj.3.5875.326.
6
A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement.一种用于人和豚鼠补体第四成分（C4）功能测定的新型一步法。
J Immunol. 1974 Aug;113(2):574-83.
7
Mesenteric lymph as a major source of serum IgA in guinea pigs and rats.肠系膜淋巴结是豚鼠和大鼠血清IgA的主要来源。
Eur J Immunol. 1973 Sep;3(9):580-4. doi: 10.1002/eji.1830030911.
8
IgA-deposits in cutaneous blood-vessel walls and mesangium in Henoch-Schönlein syndrome.过敏性紫癜中皮肤血管壁和系膜中的IgA沉积。
Lancet. 1973 Apr 21;1(7808):892-3. doi: 10.1016/s0140-6736(73)91471-2.
9
IgA glomerular deposits in renal disease.肾病中的IgA肾小球沉积物。
Transplant Proc. 1969 Dec;1(4):939-44.
10
Characterization of circulating and cutaneous IgA immune complexes in patients with dermatitis herpetiformis.疱疹样皮炎患者循环及皮肤IgA免疫复合物的特征分析
J Immunol. 1985 Sep;135(3):1760-5.

在大鼠模型中IgA对补体的体内激活作用。

In vivo activation of complement by IgA in a rat model.

作者信息

Stad R K, Bogers W M, Thoomes-van der Sluys M E, Van Es L A, Daha M R

机构信息

Department of Nephrology, University Hospital Leiden, The Netherlands.

出版信息

Clin Exp Immunol. 1992 Jan;87(1):138-43. doi: 10.1111/j.1365-2249.1992.tb06427.x.

DOI:10.1111/j.1365-2249.1992.tb06427.x
PMID:1733628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1554236/
Abstract

In this study we investigated the capacity of rat IgA to activate complement (C) in vivo in a rat model. Rat monomeric (m-), dimeric (d-) and polymeric (p-) IgA MoAbs were injected intravenously and assessed for deposition of C3 and C4 on IgA. By ELISA it was shown that both d- and p-IgA bound C3 whereas no binding of C3 by m-IgA was observed. Polymeric IgA was more efficient in binding of C3 as compared with d-IgA. However, in haemolytic assays no consistent decrease of plasma complement levels was observed except for dimeric IgA which induced a marginal consumption of AP50. When rats were pre-treated with cobra venom factor (CVF) to deplete C3, no C3 deposition was found on m-, d- or p-IgA. Neither m- nor d- or p-IgA was able to bind C4 in vivo. In agreement with the results described above, large sized polymeric IgA was shown to be taken up by Kupffer cells (KC) together with C3. No C3 was detected when rats were depleted of C using CVF. Taken together, the experimental data suggest that d- and p-IgA are able to activate C via the alternative pathway in vivo.

摘要

在本研究中，我们在大鼠模型中研究了大鼠IgA在体内激活补体（C）的能力。将大鼠单体（m-）、二聚体（d-）和多聚体（p-）IgA单克隆抗体静脉注射，并评估C3和C4在IgA上的沉积情况。通过酶联免疫吸附测定（ELISA）表明，d-IgA和p-IgA均结合C3，而未观察到m-IgA结合C3。与d-IgA相比，多聚体IgA结合C3的效率更高。然而，在溶血试验中，除了二聚体IgA引起AP50的少量消耗外，未观察到血浆补体水平持续下降。当用眼镜蛇毒因子（CVF）预处理大鼠以消耗C3时，在m-IgA、d-IgA或p-IgA上均未发现C3沉积。m-IgA、d-IgA或p-IgA在体内均不能结合C4。与上述结果一致，大型多聚体IgA显示与C3一起被库普弗细胞（KC）摄取。当使用CVF使大鼠补体耗竭时，未检测到C3。综上所述，实验数据表明d-IgA和p-IgA能够在体内通过替代途径激活补体。