Lange L S, Shiner M
Lancet. 1976 Dec 18;2(7999):1319-22. doi: 10.1016/s0140-6736(76)91972-3.
Jejunal biopsies were performed in 12 randomly chosen patients with multiple sclerosis. The jejunal mucosa was examined histologically, ultrastructurally, and by tissue immune techniques. Histology showed a normal mucosa in 7 patients, increased inflammatory-cell infiltration in 3, a partial villous atrophy in 1, and a subtotal villous atrophy in the remaining patient. Fine structural abnormalities were seen in 6 of 8 patients studied. These included microvillous changes, increase in theliolymphocytes and epithelial lysosomes, thickening of the connective tissue with or without collagen fibres, and numerous macrophages containing large amounts of membrane-bound electron-dense material. The latter was seen in 5 of the 8 mucosae examined.
对12例随机选取的多发性硬化症患者进行了空肠活检。对空肠黏膜进行了组织学、超微结构及组织免疫技术检查。组织学检查显示，7例患者黏膜正常，3例炎症细胞浸润增加，1例部分绒毛萎缩，其余1例患者为绒毛大部萎缩。在8例接受研究的患者中，有6例出现细微结构异常。这些异常包括微绒毛改变、上皮内淋巴细胞和上皮溶酶体增多、结缔组织增厚（有或无胶原纤维）以及大量含有大量膜结合电子致密物质的巨噬细胞。在8例检查的黏膜中，有5例出现了后者。
