Epifanova O I, Smolenskaya I N, Polunovsky V A
Br J Cancer. 1978 Mar;37(3):377-85. doi: 10.1038/bjc.1978.57.
The effects of various cytotoxic chemicals, as measured by viable cell counts, colony-forming ability and proliferative capacity, have been studied using Chinese hamster cells in exponential and plateau (stationary) phases of growth. The proliferating cells were altogether more sensitive to the action of the drugs than non-proliferating cells. However, imuran (azathioprine) a purine antimetabolite, was more effective against the plateau-phase cells. The observed response of cells to imuran could be detected at a wide range of concentrations (1-100 microgram/ml). These findings are discussed in view of the possible ability of imuran to interfere with active metabolic processes in non-proliferating cells.
利用处于指数生长期和平原（静止）生长期的中国仓鼠细胞，通过活细胞计数、集落形成能力和增殖能力，研究了各种细胞毒性化学物质的作用。增殖细胞总体上比非增殖细胞对药物作用更敏感。然而，嘌呤抗代谢物硫唑嘌呤对平原期细胞更有效。在很宽的浓度范围（1-100微克/毫升）内都能检测到细胞对硫唑嘌呤的反应。鉴于硫唑嘌呤可能干扰非增殖细胞中活跃代谢过程的能力，对这些发现进行了讨论。
