Wilders M M, Drexhage H A, Kokjé M, Verspaget H W, Meuwissen S G
Clin Exp Immunol. 1984 Sep;57(3):614-20.
Antigen presenting veiled cells have recently been described in cell suspensions prepared from the gut wall of patients with chronic idiopathic inflammatory bowel disease (CIBD). The normal gut wall is virtually devoid of these cells. In this report we describe a phenomenon known as peripolesis studied by phase contrast cinematography. This is a process in which lymphocytes are seen to wander around larger target cells. These could be identified ultrastructurally as Ia positive veiled cells. In most cases peripolesis was followed by lysis of the target cell. Peripolesis was recorded in cell suspensions of three out of seven patients with ulcerative colitis and in three out of nine patients with Crohn's disease; furthermore peripolesis was observed in one out of two patients with non-classifiable CIBD. In four cell suspensions showing peripolesis, cell lysis could be recorded and was especially striking in ulcerative colitis. Peripolesis involving veiled cells was previously described in delayed hypersensitivity reactions. This study lends support to the concept that delayed allergic reactivity plays a part in chronic inflammatory bowel disease. The antigens involved are, however, completely unknown.
抗原呈递的隐蔽细胞最近在取自慢性特发性炎症性肠病（CIBD）患者肠壁的细胞悬液中被描述。正常肠壁几乎没有这些细胞。在本报告中，我们描述了一种通过相差显微镜电影摄影术研究的称为围噬作用的现象。这是一个淋巴细胞围绕较大靶细胞游走的过程。这些靶细胞在超微结构上可被鉴定为Ia阳性隐蔽细胞。在大多数情况下，围噬作用之后是靶细胞的裂解。在7例溃疡性结肠炎患者中的3例以及9例克罗恩病患者中的3例的细胞悬液中记录到了围噬作用；此外，在2例无法分类的CIBD患者中的1例中观察到了围噬作用。在4例显示围噬作用的细胞悬液中，可记录到细胞裂解，这在溃疡性结肠炎中尤为明显。涉及隐蔽细胞的围噬作用先前在迟发型超敏反应中已有描述。本研究支持迟发型过敏反应在慢性炎症性肠病中起作用这一概念。然而，所涉及的抗原完全未知。
