Kotchen T A, Guyenne T T, Corvol P, Menard J
Clin Sci (Lond). 1984 Sep;67(3):365-8. doi: 10.1042/cs0670365.
Plasma renin reactivity (PRR) is the rate of angiotensin I production after addition of renin to plasma, minus endogenous renin activity. PRR is increased in plasma of patients with renal failure compared with that of normal subjects. The present study was carried out to determine if increased PRR in uraemic plasma is related to differences of endogenous active or inactive renin, endogenous renin substrate, or pH of the incubation in vitro. PRR in plasma of ten uraemic patients was greater (P less than 0.02) than that in plasma of ten normal subjects in incubations carried out at pH 7.4 and 5.7. Increased PRR was not accounted for by differences of endogenous active and inactive renin activity. After addition of renin, renin concentration (measured by direct radioimmunoassay) did not differ in normal and uraemic plasma. Renin substrate concentration, measured both indirectly and by direct radioimmunoassay, also did not differ in normal and uraemic plasma. Increased PRR in uraemic plasma is not related to alterations of renin or renin substrate concentrations. These observations are consistent with our earlier hypothesis that there is a deficiency of a renin inhibitor in uraemic plasma.
血浆肾素反应性（PRR）是向血浆中加入肾素后血管紧张素I的生成速率减去内源性肾素活性。与正常受试者相比，肾衰竭患者血浆中的PRR升高。本研究旨在确定尿毒症血浆中PRR升高是否与内源性活性或无活性肾素、内源性肾素底物或体外孵育pH值的差异有关。在pH值为7.4和5.7的孵育条件下，10例尿毒症患者血浆中的PRR高于10例正常受试者血浆中的PRR（P小于0.02）。内源性活性和无活性肾素活性的差异不能解释PRR升高的原因。加入肾素后，正常血浆和尿毒症血浆中的肾素浓度（通过直接放射免疫测定法测量）没有差异。通过间接和直接放射免疫测定法测量的肾素底物浓度在正常血浆和尿毒症血浆中也没有差异。尿毒症血浆中PRR升高与肾素或肾素底物浓度的改变无关。这些观察结果与我们早期的假设一致，即尿毒症血浆中存在肾素抑制剂缺乏。
