Foulis A K, Stewart J A
Diabetologia. 1984 Jun;26(6):456-61. doi: 10.1007/BF00262221.
The pancreatic autopsy findings of 11 children with Type 1 (insulin-dependent) diabetes mellitus are presented. Nine children died within 24 h of initial presentation. In these 'recent-onset' diabetic patients many islets were shrunken and insulin-deficient. However, large islets containing B cells were present also. Insulitis was present in eight recent-onset diabetic subjects; in these, 18% of insulin-containing islets were inflamed, but only 1% of insulin-deficient islets were thus affected. This finding supports the concept of an immunologically mediated destruction of B cells in the pathogenesis of Type 1 diabetes. Severe acinar cell atrophy was present surrounding insulin-deficient islets, but acinar tissue around insulin-containing islets was normal. These exocrine changes are thought to be related to islet-exocrine vascular connections and the effects of the various islet hormones on pancreatic acini.
本文呈现了11例1型（胰岛素依赖型）糖尿病患儿的胰腺尸检结果。9名患儿在首次发病后24小时内死亡。在这些“新发病”的糖尿病患者中，许多胰岛萎缩且缺乏胰岛素。然而，也存在含有B细胞的大胰岛。8名新发病的糖尿病患者存在胰岛炎；在这些患者中，18%含胰岛素的胰岛有炎症，但只有1%缺乏胰岛素的胰岛受到影响。这一发现支持了在1型糖尿病发病机制中B细胞受到免疫介导破坏的概念。在缺乏胰岛素的胰岛周围存在严重的腺泡细胞萎缩，但含胰岛素的胰岛周围的腺泡组织正常。这些外分泌变化被认为与胰岛 - 外分泌血管连接以及各种胰岛激素对胰腺腺泡的作用有关。
