Sirek O V, Sirek A, Cukerman E
Blood Vessels. 1978;15(4):259-65. doi: 10.1159/000158171.
The effect of hypophysectomy and replacement therapy with individual hormones such as somatotropin, cortisone, estradiol, progesterone and testosterone on the glycosaminoglycan (GAG) composition of renal arteries was studied in young beagles. The renals from normal animals showed a uniformly low total GAG content of about two thirds of the value found for aorta and coronary arteries. Neither hypophysectomy nor hormone replacement altered the GAG content, with the exception of estradiol which showed a marked effect by raising the hyaluronic acid content to nearly double the normal value. These results by being at variance with those obtained for aorta and coronary arteries provide further evidence of the differential hormone sensitivity that exists in the various segments of the canine arterial tree with respect to GAG metabolism.
在幼年比格犬中研究了垂体切除以及用生长激素、可的松、雌二醇、孕酮和睾酮等单一激素进行替代疗法对肾动脉糖胺聚糖（GAG）组成的影响。正常动物的肾脏显示总GAG含量始终较低，约为主动脉和冠状动脉所测值的三分之二。垂体切除和激素替代均未改变GAG含量，但雌二醇除外，它通过将透明质酸含量提高至正常值的近两倍而显示出显著效果。这些结果与在主动脉和冠状动脉中获得的结果不同，进一步证明了犬动脉树各节段在GAG代谢方面存在激素敏感性差异。
