Sirek O V, Sirek A, Cukerman E
Acta Diabetol Lat. 1983 Jan-Mar;20(1):21-5. doi: 10.1007/BF02629125.
Hypophysectomized young beagles were treated for 21 days with pharmacological doses of glucagon, administered intramuscularly in two daily injections of 0.5 mg each. Hyaluronic acid, heparan, dermatan and isomeric chondroitin sulphates were determined in aorta, carotid, iliac, renal, mesenteric and coronary arteries. In comparison with age-matched hypophysectomized controls, glucagon-treated dogs showed a reduction in the heparan sulphate concentration in their carotid arteries and thoracic aorta. These results indicate that glucagon has a very limited effect on arterial glycosaminoglycan content.
对垂体切除的幼年比格犬用药理剂量的胰高血糖素进行为期21天的治疗，每天分两次肌肉注射，每次0.5毫克。测定了主动脉、颈动脉、髂动脉、肾动脉、肠系膜动脉和冠状动脉中的透明质酸、硫酸乙酰肝素、硫酸皮肤素和异构硫酸软骨素。与年龄匹配的垂体切除对照犬相比，接受胰高血糖素治疗的犬颈动脉和胸主动脉中的硫酸乙酰肝素浓度降低。这些结果表明，胰高血糖素对动脉糖胺聚糖含量的影响非常有限。
