Sirek O V, Cukerman E, Sirek A
Med Hypotheses. 1978 Nov-Dec;4(6):531-9. doi: 10.1016/0306-9877(78)90045-2.
Glycosaminoglycan fractions were measured in representative large and medium sized arteries of normal, hypophysectomized and hormone treated young beagles. Hyaluronate, heparan sulphate, dermatan sulphate and the isomeric chondroitin sulphates were determined in the aortic arch, thoracic and abdominal segments, in the external iliac, superior mesenteric, renal, common carotid and coronary arteries. The hormones used for replacement therapy of hypophysectomized animals were growth hormone, thyroxine, cortisone and the sex hormones testosterone, estrogen and progesterone. The sensitivity to an individual hormone was found to differ in various segments of the arterial tree; the thoracic and abdominal aorta were most responsive but renal and superior mesenteric arteries were relatively inert. The hypothesis is advanced that arteries with a GAG metabolism highly sensitive to hormones are more prone to develop atherosclerosis than arteries that have a limited sensitivity to alterations in endocrine balance.
在正常、垂体切除和激素处理的幼年比格犬的代表性大中型动脉中测量糖胺聚糖组分。在主动脉弓、胸段和腹段、髂外动脉、肠系膜上动脉、肾动脉、颈总动脉和冠状动脉中测定透明质酸、硫酸乙酰肝素、硫酸皮肤素和异构硫酸软骨素。用于垂体切除动物替代疗法的激素有生长激素、甲状腺素、可的松和性激素睾酮、雌激素和孕酮。发现动脉树的各个节段对个体激素的敏感性不同；胸主动脉和腹主动脉反应最强烈，但肾动脉和肠系膜上动脉相对不敏感。有人提出这样的假说，即对激素的糖胺聚糖代谢高度敏感的动脉比对内分泌平衡变化敏感性有限的动脉更容易发生动脉粥样硬化。
